Effects of acupuncture on expressions of transcription factors NF-E2, YB-1, LRG47 in the SAMP10 mouse.
- Author:
Yu FU
1
;
Jian-chun YU
;
Xiao-rong DING
;
Jing-xian HAN
Author Information
- Publication Type:Journal Article
- MeSH: Acupuncture Therapy; Aging; metabolism; Animals; Brain; metabolism; Female; GTP-Binding Proteins; genetics; Gene Expression Regulation; Male; Mice; NF-E2 Transcription Factor, p45 Subunit; genetics; RNA, Messenger; analysis; Y-Box-Binding Protein 1; genetics
- From: Chinese Acupuncture & Moxibustion 2006;26(9):651-654
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the mechanism of acupuncture in delaying aging.
METHODSUsing SAMP10 mice and normal control SAMR1 as model and applying RT-PCR and DIG probed Northern blot techniques to observe expression of NF-E2, YB-1, LRG47 genes in whole brain, cortex and hippocampus in the 8-month SAMR1 control group, 8-month SAMP10 control group, 8-month SAMP10 acupuncture group and 8-month SAMP10 non-point acupuncture group.
RESULTSIn the SAMP10 control group, the expression of NF-E2, YB-1 and LRG47 were down-regulated in the whole brain, cortex and hippocampus, and after acupuncture they were up-regulated and tended to normal.
CONCLUSIONAging of the SAMP10 mouse brain is related with expression of NF-E2, YB-1 and LRG47 genes, and acupuncture can regulate the expression of NF-E2, YB-1 and LRG47 genes, improving the functions of erythrocyte series, increasing proliferation of cells and immune function of cells in anti-bacteria, hence anti-aging.
