Susceptibility of multi-resistant Gram-negative bacilli in Singapore to tigecycline as tested by agar dilution.
- Author:
Thean Yen TAN
1
;
Lily S Y NG
Author Information
- Publication Type:Journal Article
- MeSH: Acinetobacter; drug effects; Anti-Bacterial Agents; pharmacology; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae; drug effects; Escherichia coli; drug effects; Klebsiella; drug effects; Minocycline; analogs & derivatives; pharmacology; Singapore
- From:Annals of the Academy of Medicine, Singapore 2007;36(10):807-810
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTIONTigecycline is an antibiotic belonging to the glycylcycline class with in vitro activity against most Gram-negative bacteria, other than Pseudomonas aeruginosa. This study investigated the in vitro activity of tigecycline against multi-resistant isolates of Enterobacteriaceae and Acinetobacter spp. isolated from clinical specimens in Singapore.
MATERIALS AND METHODSMinimum inhibitory concentrations (MICs) to tigecycline were determined for 173 isolates of multi-resistant Escherichia coli, Klebsiella spp., Enterobacter spp. and Acinetobacter spp. using agar dilution.
RESULTSThe MIC required to inhibit the growth of 90% of organisms varied from 0.5 to 4 mg/L for the study isolates. Based on a resistance breakpoint of >or=8 mg/L, resistance rates varied from 0% to 9%.
CONCLUSIONSTigecycline demonstrates good in vitro activity against multi-resistant strains of Enterobacteriaceae, with more variable activity against multi-resistant strains of Acinetobacter spp.
