Cluster of Staphylococcus aureus and dengue co-infection in Singapore.
- Author:
Louis Y A CHAI
1
;
Poh-Lian LIM
;
Cheng-Chuan LEE
;
Li-Yang HSU
;
Yee-Leong TEOH
;
David C B LYE
;
Prabha KRISHNAN
;
Yee-Sin LEO
Author Information
- Publication Type:Case Reports
- MeSH: Adult; Cluster Analysis; Dengue; complications; epidemiology; Humans; Male; Methicillin; pharmacology; Occupations; Singapore; epidemiology; Soft Tissue Infections; transmission; Staphylococcal Infections; complications; epidemiology; therapy; transmission; Staphylococcal Skin Infections; transmission; Staphylococcus aureus; drug effects
- From:Annals of the Academy of Medicine, Singapore 2007;36(10):847-850
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTIONSingapore saw a resurgence of dengue infections in 2005. Concurrent bacterial co-infections in dengue is rare.
CLINICAL PICTUREWe report a cluster of serious methicillin-susceptible Staphylococcus aureus (MSSA) bacteraemia or severe soft tissue infection in 5 epidemiologically linked construction workers presenting with dengue and non-resolving fever.
TREATMENTSurgical intervention was indicated in 4 of the 5 patients despite appropriate antistaphylococcal therapy.
OUTCOMEAll but 1 patient were eventually discharged. Clonality and Panton-Valentine leucocidin genes were not demonstrated. Epidemiological investigations suggested that occupational contact dermatitis could have predisposed the patients to this opportunistic co-infection.
CONCLUSIONClinicians need to be vigilant to unusual manifestations of dengue which may signal a concomitant aetiology.
