Effects of growth differentiation factor-15 (GDF-15) on neurological systems, cardiovascular diseases, and cancer progression.
- Author:
Dong-Dong LIU
1
;
Yan-Ai MEI
2
Author Information
1. School of Life Sciences, Fudan University, Shanghai 200433, China.
2. School of Life Sciences, Fudan University, Shanghai 200433, China. yamei@fudan.edu.cn.
- Publication Type:Journal Article
- MeSH:
Animals;
Brain Injuries;
physiopathology;
Calcium Channels;
metabolism;
Cardiovascular Diseases;
physiopathology;
Disease Progression;
Growth Differentiation Factor 15;
metabolism;
Humans;
Inflammation;
Mice;
Neoplasms;
physiopathology;
Nervous System;
metabolism;
Potassium Channels;
metabolism;
Prefrontal Cortex;
metabolism;
Transforming Growth Factor beta;
Up-Regulation
- From:
Acta Physiologica Sinica
2017;69(1):109-121
- CountryChina
- Language:Chinese
-
Abstract:
Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor beta superfamily. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. It has been suggested that GDF-15 has neurotropic effects in the nervous system. Our studies showed that GDF-15 modulated the expression of neuronal Kand Caion channels and increased the release of excitatory transmitter in the medial prefrontal cortex of mice. GDF-15 is also involved in the complex modulation of cancer and cardiovascular disease. Here, we reviewed studies involving the modulation of GDF-15 expression and its mechanisms, the primary pathological and physiological functions of GDF-15 in neurological and cardiovascular systems, and its role in cancer progression. The biological effects and the values of GDF-15 in basic research and clinical applications were also addressed.
