Predicting factors of present hepatitis C virus infection among patients positive for the hepatitis C virus antibody.
10.3350/cmh.2013.19.4.376
- Author:
Chi Hoon LEE
1
;
Hyun Phil SHIN
;
Joung Il LEE
;
Kwang Ro JOO
;
Jae Myung CHA
;
Jung Won JEON
;
Jun Uk LIM
;
Joon Ki MIN
;
Dong Hee KIM
;
Sung Wook KANG
;
Hyun Jun JOUNG
Author Information
1. Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea. drshp@khu.ac.kr
- Publication Type:Original Article
- Keywords:
Hepatitis C;
Hepatitis C Antibodies;
Diagnosis;
Immunoassay
- MeSH:
Adult;
Aged;
Alanine Transaminase/blood;
Bilirubin/blood;
Female;
Hepacivirus/genetics;
Hepatitis C/*diagnosis;
Hepatitis C Antibodies/*blood;
Humans;
Immunoenzyme Techniques;
Male;
Middle Aged;
Odds Ratio;
Platelet Count;
Predictive Value of Tests;
RNA, Viral/analysis;
Serum Albumin/analysis
- From:Clinical and Molecular Hepatology
2013;19(4):376-381
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: To identify the predicting factors of present hepatitis C virus (HCV) infection among patients with positivity for antibodies to HCV (anti-HCV). METHODS: We analyzed patients who showed positive enzyme immunoassay (EIA) results and performed an HCV RNA test as a confirmatory test at Kyung Hee University Hospital at Gangdong from June 2006 to July 2012. The features distinguishing the groups with positive and negative HCV RNA results were reviewed. RESULTS: In total, 490 patients were included. The results of the HCV RNA test were positive and negative in 228 and 262 patients, respectively. The index value of anti-HCV, mean age, platelet counts, total bilirubin, prothrombin time international normalized ratio, albumin and alanine transaminase (ALT) levels differed significantly between the two groups. On multivariable analysis, an index value of anti-HCV >10 [odds ratio (OR)=397.27, P<0.001), ALT >40 IU/L (OR=3.64, P=0.001), and albumin <3.8 g/dL (OR=2.66, P=0.014) were related to present HCV infection. CONCLUSIONS: Although EIA is not a quantitative test, considering the anti-HCV titer with ALT and albumin levels may be helpful in predicting present of HCV infection.
