Fat deposition in skeletal muscle and its regulation.
- Author:
Li-Fang ZHENG
1
;
Pei-Jie CHEN
1
;
Yong-Zhan ZHOU
1
;
Wei-Hua XIAO
2
Author Information
1. School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
2. School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China. xiaoweihua1115@163.com.
- Publication Type:Journal Article
- MeSH:
Adipose Tissue;
physiology;
Animals;
Diabetes Mellitus;
Humans;
Muscle, Skeletal;
physiology;
Muscular Atrophy;
Muscular Dystrophies;
Obesity;
Signal Transduction
- From:
Acta Physiologica Sinica
2017;69(3):344-350
- CountryChina
- Language:Chinese
-
Abstract:
Under normal condition, there are a few lipid droplets in skeletal muscle. But in skeletal muscle acute injury, muscular dystrophy, muscle atrophy, obesity, diabetes and other pathological conditions, the fat deposition in skeletal muscle increases, which implicate that the fat deposition may play an important role in the pathogenesis of these diseases. However, the mechanisms of development and regulation of fat deposition in skeletal muscle are not clear. Clarifying the key signaling pathways and regulatory factors that affect fat deposition in skeletal muscle, and exploring new ways to improve the fat deposition in skeletal muscle will not only help to deepen our understanding of the pathogenesis of these diseases, but also provide new ideas for the treatment of these diseases. This paper reviews the research progresses and main mechanisms of fat deposition in skeletal muscle.
