Research progress of neuregulin 4 biological function.
- Author:
Fan YANG
1
;
Xiao-Nan LI
2
Author Information
1. Department of Child Health Care, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
2. Department of Child Health Care, Children's Hospital of Nanjing Medical University, Nanjing 210008, China. xnli@njmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Animals;
Apoptosis;
Cardiovascular Diseases;
Cell Proliferation;
Energy Metabolism;
Humans;
Metabolic Diseases;
Neoplasms;
Neuregulins;
physiology;
Receptor, ErbB-4;
physiology;
Signal Transduction
- From:
Acta Physiologica Sinica
2017;69(3):351-356
- CountryChina
- Language:Chinese
-
Abstract:
Neuregulin 4 (NRG4) is a kind of protein containing epidermal growth factor (EGF)-like domains, mainly expressed and secreted by brown adipocytes. It specifically activates EGF receptor ErbB4 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) to stimulate cell proliferation, inhibit apoptosis and improve energy metabolism of cells. Increasing evidence has shown that NRG4 plays an important role in epithelial cell-related diseases, cardiovascular diseases, tumors and glycolipid metabolic diseases, and therefore it could be a potential therapeutic target of some diseases.
