Potassium channels and autophagy.
- Author:
Shuo YANG
1
;
Jia LIU
2
;
Chao QU
1
;
Jia SUN
1
;
Bing-Qiang ZHANG
3
;
Ya-Ru SUN
3
;
Wei ZOU
1
Author Information
1. College of Life Sciences, Liaoning Normal University, Dalian 116081, China.
2. Department of Biological Science and Technology, Dalian University of Technology, Dalian 116024, China.
3. Key Laboratory of Cell Transplantation, Ministry of Health, Qingdao 266000, China.
- Publication Type:Journal Article
- From:
Acta Physiologica Sinica
2017;69(4):509-514
- CountryChina
- Language:Chinese
-
Abstract:
Potassium channels have multitudinous subtypes, which are widely distributed on cell membranes. They affect various cellular physiological functions through participating in processes such as resting potential formation, substance transportation, enzyme activity and cellular communication. Autophagy is a significant mechanism to maintain intracellular metabolic homeostasis. The abnormity of autophagy may lead to the occurrence and development of multiple diseases. Recently, it has been reported that Kchannels and cell autophagy are closely related. Here, we reviewed the recent research progresses on regulation of autophagy signaling, autophagy flux or autophagolysosome formation by Kchannel, and discussed the physiological significance of autophagy regulation by Kchannel.
