Cannabinoid receptor system regulates ion channels and synaptic transmission in retinal cells.
- Author:
Shao-Liu WANG
1
;
Wen-Jing QIAN
2
;
Xiao-Han WANG
2
;
Shu-Yue WANG
2
;
Wei YANG
2
;
Chuan-Qiang ZHANG
2
;
Zhong-Feng WANG
3
Author Information
1. Luoyang Vocational and Technical College, Luoyang 471000, China.
2. Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
3. Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China. zfwang@fudan.edu.cn.
- Publication Type:Journal Article
- From:
Acta Physiologica Sinica
2017;69(5):685-692
- CountryChina
- Language:Chinese
-
Abstract:
Endocannabinoid receptor system is extensively expressed in the vertebrate retina. There are two types of cannabinoid receptors, CB1 and CB2. Activation of these two receptors by endocannabinoids N-arachidonoylethanolamide (anandamine, AEA) and 2-arachidonyl glycerol (2-AG) regulates multiple neuronal and glial ion channels, thus getting involved in retinal visual information processing. In this review, incorporating our results, we discuss the modulation of cannabinoid CB1 and CB2 receptors on retinal neuronal and glial ion channels and retinal synaptic transmission.
