Neutrophils regulate the process of angiogenesis.
- Author:
Jian-Mei HAN
1
;
Meng GOU
1
;
Rong XIAO
2
Author Information
1. School of Life Science, Liaoning Normal University, Dalian 116081, China.
2. School of Life Science, Liaoning Normal University, Dalian 116081, China. xiaorong_lnnu@126.com.
- Publication Type:Journal Article
- From:
Acta Physiologica Sinica
2017;69(6):843-851
- CountryChina
- Language:Chinese
-
Abstract:
Neutrophils are one of the most abundant leukocytes present in the human blood circulation system, which could provide continuous immune surveillance. Recent studies have shown that neutrophils are closely related to angiogenesis. Neutrophils could release various cytokines, which regulate the angiogenic process by affecting the growth and migration of endothelial cells directly or indirectly. In the present review, the regulatory effects of neutrophils on angiogenic process and mechanisms are analyzed and summarized, which would provide clues for the treatment of related diseases using neutrophils as the targets in the future.
