Polymorphisms of UGT1A gene and irinotecan toxicity in Chinese colorectal cancer patients.
- Author:
Yan WANG
1
;
Jian-Ming XU
;
Lin SHEN
;
Nong XU
;
Jin-Wan WANG
;
Shun-Chang JIAO
;
Jing-Sheng ZHANG
;
San-Tai SONG
;
Jian LI
;
Han-Ying BAO
;
Lin YANG
;
Fang LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antineoplastic Agents, Phytogenic; administration & dosage; adverse effects; Antineoplastic Combined Chemotherapy Protocols; adverse effects; therapeutic use; Asian Continental Ancestry Group; genetics; Camptothecin; administration & dosage; adverse effects; analogs & derivatives; Case-Control Studies; China; Colorectal Neoplasms; drug therapy; genetics; Diarrhea; chemically induced; Fluorouracil; administration & dosage; Genetic Predisposition to Disease; Genotype; Glucuronosyltransferase; genetics; metabolism; Humans; Neutropenia; chemically induced; Polymorphism, Genetic; Young Adult
- From: Chinese Journal of Oncology 2007;29(12):913-916
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the polymorphism of UGT1A gene in Chinese, and to investigate the correlation between UGT1A polymorphism and irinotecan toxicity in colorectal cancer patients.
METHODS70 patients with advanced colorectal cancer were treated with irinotecan and 5-fluorouracil. Polymorphism analysis was performed in all those patients and 100 healthy subjects. Genomic DNA was extracted from peripheral blood and genotyped using polymerase chain reaction and direct sequencing.
RESULTS14 patients exhibiting grade 3 - 4 neutropenia (20.0%), 16 patients experienced grade 2 - 4 diarrhea (22.9%), including only 4 patients with grade 3 - 4 diarrhea (5.7%). Compared with TA6/7 and TA7/7, UGT1 A1 * 28 wild genotype TA6/6 was significantly associated with reduced toxicity (42.1% vs. 15.7%, P = 0.027). There was no significant difference in the distribution of UGT1A genotypes between colorectal cancer patients and healthy subjects.
CONCLUSIONChinese patients exhibit less irinotecan-related diarrhea due to higher frequence of UGT1A A1 * 28 wild genotype TA6/6.
