Prognosis of primary non-Hodgkin's lymphoma of the breast.
- Author:
Hai-Yi GUO
1
;
Xin-Min ZHAO
;
Jun-Ning CAO
;
Xi-Chun HU
;
Ji-Liang YIN
;
Xiao-Nan HONG
;
Jin LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Antibodies, Monoclonal; therapeutic use; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Breast Neoplasms; drug therapy; pathology; radiotherapy; Breast Neoplasms, Male; drug therapy; pathology; radiotherapy; Combined Modality Therapy; Cyclophosphamide; therapeutic use; Disease-Free Survival; Doxorubicin; therapeutic use; Female; Follow-Up Studies; Humans; Lymphoma, B-Cell, Marginal Zone; drug therapy; pathology; radiotherapy; Lymphoma, Large B-Cell, Diffuse; drug therapy; pathology; radiotherapy; Lymphoma, Non-Hodgkin; drug therapy; pathology; radiotherapy; Lymphoma, T-Cell; drug therapy; pathology; radiotherapy; Male; Middle Aged; Neoplasm Staging; Prednisone; therapeutic use; Prognosis; Proportional Hazards Models; Radiotherapy, Adjuvant; Remission Induction; Retrospective Studies; Survival Rate; Vincristine; therapeutic use; Young Adult
- From: Chinese Journal of Oncology 2008;30(3):200-202
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the clinical characteristics and prognosis of primary non-Hodgkin's lymphoma of the breast (PNHLB).
METHODSThe characteristics, treatment methods and outcomes of 45 patients with PNHLB were retrospectively analyzed. Chemotherapy including CHOP and CHOP-like regimens was administered in 43 patients, and monoclonal antibody therapy in 6 patients. Furthermore, 19 patients underwent radiotherapy after chemotherapy.
RESULTSOf these 45 patients, 37 patients had diffuse large B cell lymphoma (DLBCL), patients with T cell or mucosa-associated lymphoid tissue (MALT) lymphoma were 4, respectively. Overall response rate of first-line chemotherapy was 90.7%. Median overall survival (OS) and progression-free survival (PFS) of all patients was 6.82 and 4.25 years, respectively. The results of Cox regression model analysis showed that international prognostic index score (IPI) (RR = 5.682, P = 0.002) and Ann Arbor stage (RR = 1.836, P = 0.040) were negative independent prognostic factors for OS. Central nervous system involvement (RR = 1.107, P = 0.005) was a negative independent prognostic factor for PFS.
CONCLUSIONThe patients with PNHLB have early occurrence in lifespan. Most pathologic type was DLBCL. IPI and Ann Arbor stage are two independent prognostic factors for survival.
