Changes in expression of gelatinase in young rat condylar cartilage during functional mandibular advancement.
- Author:
Yan-min WANG
1
;
Sheng-guo WANG
;
Li ZHOU
;
Yang-xi CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cartilage; Gelatinases; Male; Mandibular Advancement; Mandibular Condyle; Matrix Metalloproteinase 2; Rats; Rats, Sprague-Dawley
- From: West China Journal of Stomatology 2007;25(3):299-305
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the changes in expression of gelatinase (MMP-2, MMP-9) in young rat condylar cartilage during functional mandibular advancement.
METHODSSixty male 5-week old SD rats were divided into experimental and control groups. The mimic functional appliances were used in experimental group rats. The animals were sacrificed after 1, 2, 4 weeks. The immunoreactivity of gelatinase was detected by immunohistochemistry.
RESULTSIn normal mandibular condylar cartilage, the immunoreactivity of MMP-2 was rather strong, the immunoreactivity of MMP-9 was very weak. Following functional mandibular advancement, the expression of MMP-9 was significantly increased (P < 0.01), but immunoreactivity of MMP-2 had no significant changes.
CONCLUSIONGelatinase plays an important role in the adaptive remondling of young rat condylar cartilage during functional mandibular advancement.
