Effects of Porphyromonas gingivalis lipopolysaccharide on collagen phagocytosis by human periodontal ligament fibroblasts.

Author: Chang-yun FANG ¹ ; Zheng SU ; Lei CHEN ; Ming-wen FAN ; Xin-chun JIAN ; Zhi CHEN
Author Information

1. Stomatological Department, Xiangya Hospital of Central South University, Changsha 410008, China.
Publication Type:Journal Article
MeSH: Collagen; Fibroblasts; Gingiva; Humans; Interleukin-6; Lipopolysaccharides; Periodontal Ligament; Periodontitis; Phagocytosis; Porphyromonas gingivalis
From: West China Journal of Stomatology 2007;25(4):339-341
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the effects of Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) on collagen phagocytosis of human periodontal ligament fibroblasts (hPDLF).
METHODSFluorescence localization and flow cytometry was used to test the collagen phygocytosis of hPDLF stimulated by the various concentration of LPS for 48 hours in vitro.
RESULTSThe collagen phygocytosis of hPDLF was increased significantly by 0.1 microg/mL LPS (P < 0.05).
CONCLUSIONThis study indicates that P. gingivalis LPS may enhance the degradation of collagen by stimulating the phagocytic activity of the hPDLF in periodontitis.