Influence of orthodontic force on osteoprotegerin and osteoprotegerin ligand mRNA expression in the inflammatory periodontal tissues.

Author: Li-wei XIAO ¹ ; Yang-xi CHEN ; Ding BAI
Author Information

1. Center of Stomatology of the Second Xiangya Hospital, Central South University, Changsha, China.
Publication Type:Journal Article
MeSH: Humans; Osteoprotegerin; Periodontitis; RANK Ligand; RNA, Messenger; Tooth Movement Techniques
From: West China Journal of Stomatology 2007;25(5):497-503
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore certain principle of how osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) take part in the periodontal tissues remodeling under the combined influence of inflammation and orthodontic force.
METHODSThe positive signals of OPG and OPGL mRNA were measured with in situ hybridzation after orthodontic tooth movement in the experimental periodontitis groups and control ones.
RESULTSThe OPG and OPGL mRNA expression intensity in the experimental group showed difference from control. All their optical density index reached a peak in day 2, respectively.
CONCLUSIONOPG and OPGL play important roles in the periodontal reconstruction induced by inflammation irritation and orthodontic force, and complex interaction could exist between the two factors.