Analyses of differential expression of Homeobox genes between lingual squamaous cell carcinoma and normal mucosa.
- Author:
Yuan-ding HUANG
1
;
Ye-xiang HUANG
;
Long-jiang LI
;
Hui XIA
;
Yu-ming WEN
Author Information
- Publication Type:Journal Article
- MeSH: Cell Differentiation; Gene Expression Regulation, Neoplastic; Genes, Homeobox; Humans; Mucous Membrane
- From: West China Journal of Stomatology 2007;25(5):500-503
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the differently expressed Homeobox genes between lingual squmaous cell carcinoma and normal mucosa.
METHODSSeven paired specimens including lingual squmaous cell carcinoma and its surrounding normal tissue were obtained from 7 patients. Customized Oligo microarray which contains numerous probes of 232 human Homeobox genes was used to analyse the results. All datas were scanned by Agilent scanner and differentiately expressed genes were sorted out.
RESULTSHomeobox gene NANOG was found up-regulated in 5 samples. PHTF2 was found down-regulated in 7 samples, and CRX, PITX1, OTEX was found down-regulated in 5 samples.
CONCLUSIONAs the key gene to cellular proliferation and differentiation, Homeobox genes is closely releverant to the oncogenesis of lingual squmaous cell carcinoma.
