Synthesis and biological effects of some furfural derivatives
- Author:
Dat Quang Nguyen
- Publication Type:Journal Article
- Keywords:
synthesis
- MeSH:
Chemical synthesis;
Physiological Effects of Drugs;
Furaldehyde;
Analogs & derivatives
- From:Pharmaceutical Journal
1999;282(10):10-12
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Nitration of furfural to give 5-nitrofurfural diacetate (NFD). By the condensation of NFD with 2-butanone (or acethylacetone), two cetone a, b-ethylenic deriva-tives (I,II) were formed. Condensation of furfural with acetone to give (XII). Condensation of I (or II or XII) with various H2N-B compounds to give 15 derivatives (III-XI, XIII- XVIII). The structure of the obtained products were characterized by elemental analysis and IR and 1H-NMR spectroscopy.The synthesized compounds were tested for biological ethylenic activities such as antibacterial and antifungal. Among these, two cetone a, b-ethylenic derivatives of 5-nitrofurfural (I,II) showed a high antibacterial activity on 10 strains of bacteria and a high antifungal activity against Candida albicans.
