Contents of serum Cyst-C and urinary microalbumin in children with Henoch-Schonlein purpura.
- Author:
Xiao-Ping LU
1
;
Wen-Juan SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Albuminuria; etiology; Child; Child, Preschool; Creatine; blood; Cystatin C; blood; Female; Glomerular Filtration Rate; Humans; Kidney Diseases; diagnosis; etiology; Male; Purpura, Schoenlein-Henoch; blood; complications; urine
- From: Chinese Journal of Contemporary Pediatrics 2009;11(5):346-348
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical significance of serum Cyst-C and urinary microalbumin in early renal impairment in children with Henoch-Schonlein purpura (HSP).
METHODSForty-eight children with HSP and who had normal serum creatinine level and 31 healthy children were enrolled. Contents of serum Cyst-C and urinary microalbumin were measured using ELISA and immunoturbidimetry, respectively. Urinary routine examination was performed in children with HSP. The contents of serum Cyst-C and urinary microalbumin were re-examined one month after treatment (recovery phase).
RESULTSThe contents of serum Cyst-C (2.24+/- 0.81 mg/L) and urinary microalbumin (20.04+/- 10.32 mg/L) in the HSP group at the acute phase were significantly higher than those in the control (0.85+/- 0.20 and 2.30+/- 1.38 mg/L respectively; P< 0.01). Serum Cyst-C (1.70+/- 0.30 mg/L) and urinary microalbumin contents (13.20+/- 8.16 mg/L) were significantly reduced at the recovery phase compared with those at the acute phase in the HSP group (P< 0.01). The proportion of urinary routine abnormality (33.3%) was significantly lower than that of urinary microalbumin (68.8%) and serum Cyst-C abnormalities (72.9%) in the HSP group (P< 0.01).
CONCLUSIONSSerum Cyst-C and urinary microalbumin may serve as indexes in the assessment of early renal impairment in children with HSP.