Progress on the study of HLA-Cw--review.
- Author:
Hong-Jing MA
1
;
Lu-Lu XIAO
;
Kun-Yuan GUO
Author Information
1. Department of Hematology, Zhujiang Hospital, The First Military Medical University, Guangzhou 510282, China.
- Publication Type:Journal Article
- MeSH:
Autoimmune Diseases;
immunology;
Graft vs Host Disease;
etiology;
HLA-C Antigens;
genetics;
physiology;
Humans;
Neoplasms;
immunology;
Receptors, Immunologic;
metabolism;
Receptors, KIR;
Virus Diseases;
immunology
- From:
Journal of Experimental Hematology
2004;12(5):699-703
- CountryChina
- Language:Chinese
-
Abstract:
HLA-Cw belongs to classic HLA-I gene, HLA-Cw molecules have high polymorphism like HLA-A and B molecules. They distribute extensively on the surfaces of karyote, not only presenting endogenetic antigen to CD8+ T cells to induce specific killing effect, but also participating in immunologic reaction as the ligands of killer cell immunoglobulin-like receptor (KIR). Thus it has been valued for their relations to diseases and the functions in transplantation immunity, anti virus and anti-tumor immunity.
