Progress on research and clinical application of interleukin-11 in treatment of leukemia--review.
- Author:
Qin-Rong ZHANG
1
Author Information
1. Depatrment of Hematology, The First Affiliated Hospital, Suzhou University, Suzhou 215006, China.
- Publication Type:Journal Article
- MeSH:
Graft vs Host Disease;
prevention & control;
Hematopoietic Stem Cell Transplantation;
Humans;
Interleukin-11;
adverse effects;
pharmacology;
therapeutic use;
Kidney;
drug effects;
Leukemia;
drug therapy;
Liver;
drug effects
- From:
Journal of Experimental Hematology
2004;12(5):718-720
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-11 (IL-11) is a multifunctional cytokine that directly acts on hematopoietic progenitors, macrophage, T cells, epithelial cells and hepatocytes, as well as promotes hematopoiesis, regulates immunity, protects mucosa and epithelium, and has the effect of anti-inflammatory. Preclinical and clinical studies have demonstrated that IL-11 effectively accelerates the recovery of peripheral blood platelets of acute leukemia patients after chemotherapy. In the hematopoietic stem cell transplantation, IL-11 prevents and treats the graft-versus-host disease leading to the effect of graft-versus-leukemia. Synergizing with G-CSF, IL-11 mobilizes hematopoietic progenitors and stem cells from bone marrow to peripheral blood with higher efficiency. Progress on research and clinical application of IL-11 in treatment of leukemia was reviewed in this paper.
