Multiple factors in erythrocytic recovery following ABO-incompatible allogeneic HSCT.
- Author:
Xiao-Jun HUANG
1
;
Dai-Hong LIU
;
Lan-Ping XU
;
Wei HAN
;
Qian JIANG
;
Yu-Hong CHEN
;
Yao-Chen ZHANG
;
Kai-Yan LIU
;
Li BAO
;
Dao-Pei LU
Author Information
1. Institute of Hematology, People Hospital, Peking University, Beijing 100044, China.
- Publication Type:Journal Article
- MeSH:
ABO Blood-Group System;
Adolescent;
Adult;
Blood Group Incompatibility;
blood;
complications;
Erythrocyte Count;
Erythrocytes;
cytology;
Female;
Graft vs Host Disease;
etiology;
prevention & control;
Hematopoietic Stem Cell Transplantation;
adverse effects;
methods;
statistics & numerical data;
Humans;
Leukemia;
therapy;
Male;
Middle Aged;
Proportional Hazards Models;
Regression Analysis;
Retrospective Studies;
Transplantation, Homologous
- From:
Journal of Experimental Hematology
2004;12(6):812-815
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate various factors influening erythrocyte recovery following ABO-incompatible allogeneic HSCT. 157 patients following ABO-incompatible allogeneic HSCT were selected for the investigation. Cox regression analysis were used to identify the statistically significant factors including sex, age, schemes of transplantation, HLA-matched, mismathed, conditioning regimens, preventive measures for GVHD, occurrence of grade I-II GVHD, CMV infections and types of incompatible blood group. The results showed that minor ABO-incompatible, number of mononuclear cells infused, age of patients and unrelated BMT were four important main factors influening the erythrocyte recovery. In conclusion, the erythrocyte recovery is more quick in patients with minor ABO-incompatible and more number of mononuclear cells infused, while it is slow in patents with old age and unrelated BMT.
