Study on bone marrow microvascular density in hematological diseases.
- Author:
Wu GAO
1
;
Yan-Qiu SONG
;
Wei LI
;
Guan-Jun WANG
Author Information
1. Department of Hematology and Oncology, The First Hospital of Jilin University, Changchun 130021, China.
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Bone Marrow;
blood supply;
pathology;
Hematologic Diseases;
blood;
pathology;
Humans;
Leukemia;
blood;
pathology;
Microcirculation;
Neovascularization, Pathologic;
blood;
pathology
- From:
Journal of Experimental Hematology
2004;12(6):852-854
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the state and significance of bone marrow angiogenesis in hematological diseases, bone marrow microvascular density (BM-MVD) in plastic-embedded section was examined using acetone-fixed bone marrow tissues embedded in glycol-methacrylate (GMA) resin and by the method of immunohistochemistry. The results showed that bone marrow MVD increased greatly in newly diagnosed hematological malignancies before treatment. BM-MVD in patients with acute leukemia decreased down to the normal range as the controls at the time of complete remission. In the non-remission group, BM-MVD decreased less, but when relapsed it increased again up to the same range as the newly diagnosed hematological malignancies, significant increase of BM-MVD was found in patients with anemia, but in less degree than that in hematological malignancies. It is concluded that bone marrow angiogenesis plays a key role in the pathogenesis and development of hematological malignancy. Antiangiogenic therapy may be able to constitute a novel strategy for the treatment of hematological malignancies including leukemia.
