Neuroimaging of Hemichorea-Hemiballism.
- Author:
Sang Hun YI
1
;
Tae Beom AHN
;
Seon Hee BU
;
Deog Yoon KIM
Author Information
1. Department of Neurology, Kyung Hee University College of Medicine, Seoul, Korea. ricash@hanmail.net
- Publication Type:Original Article
- Keywords:
Hemichorea;
Hemiballism;
Subthalamic nucleus;
SPECT
- MeSH:
Basal Ganglia;
Brain;
DNA;
Dyskinesias;
Humans;
Hyperglycemia;
Neuroimaging*;
Perfusion;
Subthalamic Nucleus;
Thalamus;
Tomography, Emission-Computed, Single-Photon
- From:Journal of the Korean Neurological Association
2007;25(3):318-323
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Hemichorea-Hemiballism (HCHB) can be caused by various diseases such as cerebrovascular disease, hyperglycemia, tumor, and inflammatory diseases. However, there are a few case studies using functional imaging such as single photon emission computed tomography (SPECT). METHODS: In this study, we included patients with HCHB. The patients with hyperglycemia over 250 mg/dl or high signal intensity on T1 weighted imaging were excluded. Clinical and neuroimaging characteristics of the patients were obtained and analyzed. RESULTS: We included 20 patients (M:F=12:8, mean age=67.1+/-15.3). Sixteen patients were presented with hemiballism and four with hemichorea. Six patients had no structural lesions causing HCHB. Subthalamic nucleus was the causative lesion in 6 patients. Other lesions associated with HCHB were basal ganglia, thalamus, and cortices. In a patient without structural lesion, anti-double stranded DNA antibody was detected. Brain SPECT showed not only perfusion abnormalities in the cases without structural lesions but also additional abnormalities in those with definite lesions. CONCLUSIONS: Various mechanisms were related to the development of HCHB. Functional imaging such as SPECT and immunological work-up is needed to investigate the underlying pathomechanism of HCHB.
