Synthesis of some derivatives of 4(3H)-quinazolinone with biological effects from N-acetylanthranilic acid
- Author:
Vinh Ngoc Nguyen
- Publication Type:Journal Article
- Keywords:
synthesis
- MeSH:
Chemical synthesis;
Physiological Effects of Drugs;
N-acetylanthranilic acid
- From:Pharmaceutical Journal
1999;282(10):19-22
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
4(3H)-quinazolinone derivatives were synthesized by the condensation of N-acetylanthranilic acid with aromatic amines or heteroaromatic amines, respectively. The obtained compounds were characterized by their melting point, elemental analysis and the mass, ultraviolet, infrared, 1H and 13C NMR spectra. The obtained derivatives of 4(3H)-quinazolinone were also biologically screened such as: hypnotic, analgesic, antibacterial and cytotoxic activity. 3-(2-hydroxy-3-pyridinyl)-2-methyl-4(3H)-quinazolinon (6) showed potential analgesic activity. No compounds showed hypnotic, cytotoxic and antibacterial activity.
