Expression of neutral endopeptidase and motility-related protein-1 in cutaneous malignant melanoma.
- Author:
Yan WU
1
;
Xiao-bing ZHANG
;
Hou-jun LIU
;
Li-duan ZHENG
;
Jia-wen LI
;
Yun LIN
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, CD; metabolism; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Melanoma; metabolism; pathology; secondary; Membrane Glycoproteins; metabolism; Neoplasm Invasiveness; Neoplasm Staging; Neprilysin; metabolism; Skin Neoplasms; metabolism; pathology; secondary; Tetraspanin-29
- From: Chinese Journal of Pathology 2007;36(7):466-469
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of neutral endopeptidase (CD10) and motility-related protein-1 (CD9) in malignant melanoma and their clinical significance.
METHODSImmunohistochemical study for CD10 and CD9 using Streptavidin-biotin complex technique was carried out in 48 cases of primary cutaneous malignant melanoma (CMM), 23 cases of metastatic melanoma and 23 cases of benign nevus.
RESULTSThe positivity rate of CD10 was highest in metastatic melanoma and lowest in benign nevus (P < 0.01). In contrast, the positivity rate of CD9 in metastatic melanoma was lower than that in CMM (P < 0.05). The expression of CD9 was inversely correlated with that of CD10 in malignant melanoma (CMM: r = -0.40, P = 0.005; metastatic MM: r = -0.44, P = 0.034). The expression of CD10 and CD9 in CMM also correlated with tumor histology, Clark's level of invasion and presence of nodal metastasis. A similar relationship was also observed for CD10 and CD9 expression in stromal fibroblasts of CMM (r = -0.43, P = 0.007).
CONCLUSIONSCD10 and CD9 expression correlates with the invasiveness and metastatic potential of malignant melanoma; both factors may demonstrate a counteracting effect. These two markers have potential implications in prognostic assessment of CMM. Stromal fibroblasts may also play an important role in the progression of CMM.
