Relationship between p53 Arg72Pro polymorphism and cervical carcinoma in Uigur and Han women in Xinjiang.
- Author:
Xing-zheng ZHENG
1
;
An-qiang YANG
;
Xiao-lin PAN
;
Li-li ZHENG
;
Qiu-yuan ZHOU
;
Xin-min LI
;
Xiao-ling WANG
;
Li-hua YAN
;
Hong-an LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Alleles; Base Sequence; China; ethnology; Codon; DNA, Neoplasm; genetics; Exons; Female; Gene Frequency; Genes, p53; Genetic Predisposition to Disease; ethnology; Human papillomavirus 16; isolation & purification; Humans; Middle Aged; Molecular Sequence Data; Papillomavirus Infections; ethnology; Polymorphism, Genetic; Tumor Suppressor Protein p53; genetics; Uterine Cervical Neoplasms; ethnology; genetics; virology; Young Adult
- From: Chinese Journal of Pathology 2007;36(8):511-515
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between p53 Arg72Pro polymorphism and cervical carcinomas HPV-associated cervical carcinoma in Uigur and Han women.
METHODSThe distribution and frequencies of p53 Arg72Pro genotypes were determined by PCR-RFLP in 152 cases of cervical carcinoma in ethnic Uigur women with 110 cases of normal control and 120 cases of cervical carcinoma in Han women with 122 cases of normal control.
RESULTSThe omni-constituent ratio of p53 genotype was statistically different between cervical carcinoma and normal control groups in the Uigur (chi(2) = 7.196, P < 0.05) group. The proportion of Arg/Arg was higher in cervical carcinomas than that in control. The omni-constituent ratio of p53 genotype was statistically different between cervical carcinoma and normal control groups in Han (chi(2) = 8.231, P < 0.025). The proportion of Pro/Pro was higher in cervical carcinoma than that in normal control. The omni-constituent ratio was statistically different between HPV 16 positive and negative groups of cervical carcinoma in the Uigur group (chi(2) = 7.177, P < 0.05). The proportion of Arg/Arg was higher in HPV 16 positive group than that in HPV 16 negative group.
CONCLUSIONSp53 Arg72Pro polymorphism may be associated with the development of cervical carcinoma in Uigur and Han women in Xinjiang. p53 Arg/Arg genotype may be a genetically susceptible factor to HPV-associated cervical carcinoma in Uigur. p53 Pro/Pro genotype may be a genetically susceptible factor to cervical carcinoma in Han. There may be different susceptibilities to cervical cancer between Uigur and Han women in Xinjiang.
