The Effect of Mitomycin on the Experimental Filtering Surgery.
- Author:
Woo Jung KIM
1
;
Jee Youn KIM
;
Dong Ho YOUN
Author Information
1. Department of Ophthalmology, Borame City Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Filtering bleb;
Glaucoma filtering surgery;
Mitomycin
- MeSH:
Blister;
Collagen;
Fibroblasts;
Filtering Surgery*;
Glaucoma;
Lip;
Loa;
Mitomycin*;
Porifera;
Rabbits
- From:Journal of the Korean Ophthalmological Society
1993;34(6):530-539
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In tiis study, an expenmental model of glaucoma filtering surgery in rabblts was used to evaluate the effect of single intraoperative application of Mitomycin Full-thickness filtering surgery, posterior lip sclerectomy, was performed after application of 0.5mg/ml Mitomycin-soaked Week-Cel(TM) sponge for 5 minutes in one eye of 15 pigmented rabbits and was irrigated copiously with balanced salt solution(BSS(TM)). The same procedure was done in the contralateral eye as a control, using BSS(TM). In Mitomycin-treated group, the filtering blebs were more prominent with sparse vascular tissues and were maintained through postoperative 8 weeks or more. Histologically, there loas was amount of inflammatory reactions in Mitomycin-treated group. The fibroblastic activity and proliferations of the collagen were also suppessed markedly in Mitomycin-treated group. These results suggest that a single intraoperative application of Mitomycin can be used adjunctively to improve the success rate of glaucoma filtering surgery.
