Relationship between the endothelial barrier and vascular permeability after burns and its mechanism.
- Author:
Qiao-bing HUANG
1
Author Information
1. Department of Pathophysiology, Key Laboratory for Shock and Microcirculation Research of Guangdong, Southern Medical University, Guangzhou 510515, PR China. bing@fimmu.com
- Publication Type:Journal Article
- MeSH:
Actins;
metabolism;
Burns;
metabolism;
physiopathology;
Capillary Permeability;
Cytoskeleton;
metabolism;
Endothelium, Vascular;
metabolism;
Humans;
Myosin-Light-Chain Kinase;
metabolism;
rho-Associated Kinases;
metabolism
- From:
Chinese Journal of Burns
2007;23(5):324-326
- CountryChina
- Language:Chinese
-
Abstract:
Massive burn trauma is characterized by hypovolemic shock induced by the loss of plasma from vessels. The major reasons for this systemic microvascular leakage in burns include an increase in vascular permeability triggered by inflammatory mediators and the increase of vascular hydrostatic pressure caused by vessel dilation. The maintenance of normal vascular permeability depends on the integrity of endothelial barrier function regulated by the interaction of intracellular junctions, cell-matrix adhesion and the cytoskeleton contractile force. This review summarizes some recent discovery in endothelial mechanisms during burn-induced vascular hyperpermeability.
