A potential mechanism for impaired wound healing--cutaneous environmental disorders in diabetes mellitus.
- Author:
Shu-Li-Ang LU
1
;
Ting XIE
;
Yi-Wen NIU
Author Information
1. Department of Burns, Ruijin Hospital, Medical College of Shanghai JiaoTong University, Shanghai 200025, PR China.
- Publication Type:Journal Article
- MeSH:
Diabetes Mellitus;
metabolism;
physiopathology;
Humans;
Skin;
metabolism;
Wound Healing
- From:
Chinese Journal of Burns
2008;24(1):3-5
- CountryChina
- Language:Chinese
-
Abstract:
Impaired wound healing in diabetes is a significant clinical problem which is thought to be associated with neuropathy and angiopathy previously . The present study indicates that accumulation of glucose and glycometabolic products in skin tissue, as the result of glycometabolic disorders, which contributes to cutaneous environmental alterations in diabetes mellitus, and subsequently induces the abnormal cell behaviors, cytokine alteration and matrix modification. Thus, diabetic neuropathy and angiopathy might be regarded as the pathological outcome of cutaneous environmental alterations. In conclusion, glycometabolism disorders could be described as one of the initial events for the alteration involving in the underlying cutaneous disorder which impair healing process. The related research focuses on the initial event of controlling disorders in wound healing and therefore contribute to providing the strategy of treatment as based on these approaches.
