Relationship between fibrinogen Bß-148C/T polymorphism and coronary artery lesions in children with Kawasaki disease.
- Author:
Jie GAO
1
;
Hong-Yang WANG
;
Nai-Jun WU
;
Shu-Hua ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Child, Preschool; Coronary Artery Disease; etiology; Female; Fibrinogen; analysis; genetics; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome; complications; genetics; Polymorphism, Genetic
- From: Chinese Journal of Contemporary Pediatrics 2010;12(7):518-520
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the possible relationship between coronary artery lesions and fibrinogen Bbeta-148 C/T polymorphism in children with Kawasaki disease.
METHODSFast blood samples were taken from 36 children with Kawasaki disease (21 had coronary artery lesions) and 49 age- and gender-matched healthy children (control group). Plasma levels and molecular reactivity of fibrinogen were measured with Assist Plasma Fibrinogen Activity Assay System. Polymerize chain reaction and restriction enzyme digestion were used to detect the genotypes of fibrinogen Bbeta-148C/T gene polymorphism.
RESULTSThe plasma fibrinogen levels in patients with coronary artery lesions were significantly higher than those in patients without coronary artery lesions and in the control group. T allele frequency in patients with Kawasaki disease was significantly higher than that in the control group. The patients with coronary artery lesions had more increased T allele frequency compared with the patients without coronary artery lesions.
CONCLUSIONSPlasma fibrinogen levels and fibrinogen Bbeta-148C/T polymorphism are associated with coronary artery lesions in children with Kawasaki disease.
