A serial study of in cytogenetic change and morphology on the tetra-arsenic tetra-sulfide treatment in untreated or recurrent acute promyelocytic leukemia.
- Author:
Hui LIU
1
;
Jing-ying QIU
;
Dao-pei LU
;
Bo HONG
;
Hui-lin SHI
;
Yan SHI
;
Hui DANG
;
Qi HE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Arsenicals; therapeutic use; Bone Marrow; pathology; Chromosomes, Human, Pair 15; Chromosomes, Human, Pair 17; Female; Humans; In Situ Hybridization, Fluorescence; Leukemia, Promyelocytic, Acute; drug therapy; genetics; pathology; Male; Middle Aged; Recurrence; Sulfides; therapeutic use; Translocation, Genetic
- From: Chinese Journal of Oncology 2003;25(2):163-167
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the morphologic and cytogenetic change in acute promyelocytic leukemia (APL) patients during the tetra-arsenic tetra-sulfide (TATS) treatment and the mechanism of TATS.
METHODSThe bone marrow cells of 13 newly diagnosed and 7 recurrent APL patients were studied through FISH and morphology during the TATS treatment by special and repeated marrow culture.
RESULTSCytomorphological study of 8 cases (6 untreated and 2 recurrent) showed that TATS could differentiate APL cells forward to mature granulocytes. There was obvious correlation between the reduced t (15; 17) positive cells and the reduced APL cells (r range 0.7298 - 0.9989). Except one patient with t (11; 17), 19 (13 untreated and 7 recurrent) with translocation t (15; 17) achieved clinical CR including 16 who achieved cytogenetic CR.
CONCLUSIONTATS has a differentiation-inducing effect on untreated and recurrent APL, with haematological CR and cytogenetic CR achieved. Measurement of t (15; 17) positive cells by FISH technique can reflect the change of APL cells objectively.
