Intraoperative radiotherapy for 30 esophageal carcinoma patients.
- Author:
Fu-lai YAN
1
;
Xing-ming ZHOU
;
Qi-xun CHEN
;
Rong-xuan JIANG
;
Jun FANG
;
Yan-hong LIAN
;
Xiao ZHENG
;
Xiu-yong CHEN
;
Yuan ZHU
;
Xiao-yun DI
;
Jian WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Combined Modality Therapy; Esophageal Neoplasms; mortality; therapy; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy Dosage
- From: Chinese Journal of Oncology 2003;25(2):178-180
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the complications and treatment results of intraoperative radiotherapy (IORT) for esophageal carcinoma.
METHODSSixty patients with thoracic esophageal carcinoma underwent esophagectomy through right thoractomy, 30 patients of whom received IORT of 15 - 25 Gy.
RESULTSIn patients who underwent IORT, 2 cases of pneumonitis, 1 case of anastomotic leak and 1 case of incisional wound infection were found. In patients underwent surgery only, 1 case of thoracic empyema and 1 case of anastomotic leak were found. All the complications ultimately healed. There was no operative mortality. During the follow-up of 3 years, in patients who underwent IORT, 2 of 3 died of radiation pneumonitis 24 and 26 months after IORT with one complicated with bronchoesophageal fistula. One of 3 died of multiple lung metastases. The 3-year survival rate was 88.0% (22/25) in IORT group and 76.0% (19/25) in surgery only group.
CONCLUSIONIntraoperative radiotherapy can reduce locoregional recurrence if performed to thoracic esophageal carcinoma patients without surgical contraindication or distant metastasis. Radiation pneumonitis, a common complication difficult to manage, implies a poor prognosis and, consequently, the lung and bronchus should be protected from the radiation.