Treatment of second primary malignant tumor induced by radiotherapy.
- Author:
Guo-hao WU
1
;
Fu-jin CHEN
;
Zong-yuan ZENG
;
Hao LI
;
Guo-wu LIN
;
Ming SONG
;
Mao-wen WEI
;
Guang-pu XU
;
An-kui YANG
;
Wen-kuan CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Humans; Male; Middle Aged; Neoplasms, Radiation-Induced; diagnosis; mortality; therapy; Neoplasms, Second Primary; diagnosis; mortality; therapy; Radiotherapy; adverse effects; Survival Rate
- From: Chinese Journal of Oncology 2003;25(3):275-277
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the diagnosis and treatment of a second primary malignant tumor induced by previous radiotherapy.
METHODSFrom March 1970 to March 1997, 108 nasopharyngeal cancer (NPC) patients who developed a second primary malignant tumor induced by radiotherapy were treated. There were squamous carcinoma 43 (39.8%), sarcoma 26 (24.1%), malignant fibrous histiocytoma 14 (13.0%), adenoid cystic carcinoma 12 (11.1%), thyroid papillary adenocarcinoma 8 (7.4%) and malignant melanoma 5 (4.6%). Fifty patients underwent operation, 32 received radiotherapy, 18 received chemotherapy and 8 received operation combined with chemotherapy.
RESULTSThe 3- and 5-year tumor-free survival rates were 64.0% and 36.0% in the operation group. They were 34.4% and 18.8% in the radiotherapy group.
CONCLUSIONSurgery, if not contra-indicated, is the first choice for the second primary malignant tumor induced by radiotherapy. Aggressive treatment for these patients is, hence, indicated clinically.
