Expression of annexin II in human esophageal squamous cell carcinoma.
- Author:
Xun ZHANG
1
;
Hui-ying ZHI
;
Jian ZHANG
;
Xiu-qin WANG
;
Chuan-nong ZHOU
;
Min WU
;
Yun-tian SUN
;
Zhi-hua LIU
Author Information
- Publication Type:Journal Article
- MeSH: Annexin A2; biosynthesis; genetics; Carcinoma, Squamous Cell; metabolism; pathology; Cell Differentiation; Down-Regulation; Esophageal Neoplasms; metabolism; pathology; Female; Humans; Male; RNA, Messenger; biosynthesis; genetics
- From: Chinese Journal of Oncology 2003;25(4):353-355
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the expression of annexin II in human esophageal squamous cell carcinoma (ESCC) and its relation with clinicopathological data.
METHODSThe expression of annexin II mRNA and protein in paired cancer tissues and their adjacent quasi-normal tissues were detected by RT-PCR, immunohistochemical method and densitometric scanning. The relation between annexin II expression and the status of tumor differentiation was analyzed.
RESULTSThe expression of annexin II was significantly lower in the tumor tissue than that in its paired normal counterpart both in mRNA and protein level (P < 0.05, P < 0.01). The protein expression of annexin II was significantly lower in moderately and poorly differentiated tumors than those in well differentiated ones (P < 0.05).
CONCLUSIONDown-regulation of annexin II in esophageal carcinogenesis may play an important role in squamous cell differentiation.
