Alternation and significance of CD4(+)CD45RA(+) and CD4(+)CD45RO(+) T cells in peripheral blood of colorectal cancer patients.
- Author:
Gang XIAO
1
;
Gang ZHAO
;
Xiao-dong XU
;
Jing-hai SONG
;
Mei-xiong HUANG
;
Jun-min WEI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; CD4-Positive T-Lymphocytes; immunology; Colorectal Neoplasms; immunology; pathology; surgery; Female; Humans; Leukocyte Common Antigens; blood; Male; Middle Aged; Neoplasm Staging; Postoperative Period; Prognosis
- From: Chinese Journal of Oncology 2003;25(4):362-364
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the alternation and significance of CD4(+)CD45RA(+) T cells and CD4(+)CD45RO(+) T cells in peripheral blood of colorectal cancer patients.
METHODSThe expression of CD4(+) T cells, CD4(+)CD45RA(+) T cells and CD4(+)CD45RO(+) T cells in peripheral blood of 60 colorectal cancer patients were detected with flow cytometry pre-operatively and 1, 3 months post-operatively, compared with those of 10 healthy persons.
RESULTSCD4(+) T cells expression of colorectal cancer patients was the same as the healthy persons. The proportion of CD4(+)CD45RO(+) T cells of colorectal cancer patients was higher, which descended post-operatively, especially in Dukes A and B patients, while CD4(+)CD45RA(+) T cells showed the opposite findings.
CONCLUSIONCD4(+)CD45RA(+) T cells and CD4(+)CD45RO(+) T cells, playing an important immune effect in colorectal cancer patients, is closely related to stage and prognosis.
