Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1beta production from human phagocytes.
10.3858/emm.2009.41.8.064
- Author:
Jae Woong SHIM
1
;
Seong Ho JO
;
Sang Doo KIM
;
Ha Young LEE
;
Jeanho YUN
;
Yoe Sik BAE
Author Information
1. Department of Biochemistry College of Medicine, Dong-A University Busan 602-714, Korea. yoesik@donga.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
cell migration inhibition;
chemotaxis, leukocyte;
interleukin-1beta;
lysophosphatidylglycerol;
phagocytes;
receptors, formyl peptide
- MeSH:
Chemotaxis, Leukocyte/*drug effects;
Humans;
Interleukin-1beta/*biosynthesis;
Lysophospholipids/*pharmacology;
Monocytes/drug effects/immunology/metabolism/physiology;
Neutrophils/drug effects/immunology/metabolism/physiology;
Peptides/metabolism/pharmacology;
*Phagocytes/drug effects/immunology/metabolism/physiology;
Receptors, Formyl Peptide/*metabolism;
Receptors, Lipoxin/*metabolism;
Serum Amyloid A Protein/metabolism/pharmacology
- From:Experimental & Molecular Medicine
2009;41(8):584-591
- CountryRepublic of Korea
- Language:English
-
Abstract:
In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1beta production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1beta production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.
