In vivo effect of Shu-Gan-Liang-Xue decoction on estrogen.
- Author:
Ping-ping LI
1
;
Wei WANG
;
Yu-quan XIE
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drug Synergism; Endometrium; drug effects; pathology; Estrogens; blood; Female; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; Organ Size; drug effects; Tamoxifen; pharmacology; Uterus; drug effects
- From: Chinese Journal of Oncology 2003;25(5):445-447
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the in vivo effect of traditional chinese medicine (TCM) Shu-Gan-Liang-Xue (SGLX) decoction on estrogen in vivo in mice.
METHODSMice were randomly divided into control, tamoxifen (TAM), SGLX and SGLX + TAM groups. After SGLX decoction had been given to mice for 21 days, the serum hormone level of mice was tested by radioimmunological method, uterine weight index was obtained by uterine weight divided by body weight. Endometrial change was pathologically observed.
RESULTSSGLX decoction reduced the level of serum estrogen more than the control with significant difference (P < 0.001). Uterine weight index was more lowered in the SGLX group than the control giving a difference but not significant. The endometrium in the SGLX group showed no change when compared with that of the control, but the SGLX + TAM group showed slightly more endometrial hyperplasia than the TAM group.
CONCLUSIONSGLX decoction, having synergistic effect on TAM, can reduce serum hormone level and alleviate the endometrial hypertrophy side effect of TAM.
