Preliminary study on gene expression profile of endometrial adenocarcinoma.
- Author:
Huai-jun ZHOU
1
;
Yi-fu SHI
;
Juan-qing LI
;
Jin-quan CUI
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; genetics; Aurora Kinases; Cell Cycle Proteins; Endometrial Neoplasms; genetics; Female; GPI-Linked Proteins; Gene Expression Profiling; Humans; Membrane Proteins; genetics; Protein-Serine-Threonine Kinases; genetics; Proto-Oncogene Proteins c-kit; genetics
- From: Chinese Journal of Oncology 2003;25(5):464-467
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine candidate genes of endometrial adenocarcinoma.
METHODSTo compare the gene expression profile in 2 endometrial adenocarcinoma tissues and 2 normal endometria by HGEC-40s GeneChip probe including 4096 genes array. Expression differences between normal and malignant tissue groups were measured by GenePixPro3.0 software.
RESULTS350 genes with a ratio below 0.5 and above 2.0 showed discrimination between normal and malignant groups. Thirty three genes with ratio above 3 were up-regulated, forty-four genes with ratio below 0.3 were down-regulated.
CONCLUSIONThe overexpression of oncogenes with their disturbed or constitutively activated signal transduction cascades alone or in combination with the mutation-induced silencing of tumor suppressor genes is associated with malignant transformation.
