Chondrocyte apoptosis in rabbit temporomandibular joint after anterior disc displacement.
- Author:
Jianying FENG
1
;
Zhiyuan GU
;
Zhiqiang CAO
;
Shibata TAKANORI
;
Jian HU
;
Jiaping PENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; Chondrocytes; pathology; In Situ Nick-End Labeling; Joint Dislocations; physiopathology; Rabbits; Temporomandibular Joint; physiopathology; Temporomandibular Joint Disc; physiopathology
- From: Chinese Journal of Stomatology 2002;37(3):200-202
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo study the chondrocyte apoptosis in rabbit temporomandibular joint after anterior disc displacement.
METHODSExperimental anterior disc displacement was induced surgically in 20 Japanese rabbits without opening their temporomandibular joint bursas. Histopathologic and apoptotic (TUNEL) analysis was used to evaluate the changes in articular cartilage, disc and synovium.
RESULTSCondyle chondrocyte showed apoptosis most obviously at 1 or 2 weeks after surgery, and apoptotic cells concentrated in proliferative zone and hypertrophic zone. 4 or 6 weeks after surgery, the joint went into a remodelling period.
CONCLUSIONSChondrocyte apoptosis in temporomandibular joint will be activated after anterior disc displacement, which initiates the remodelling in temporomandibular joint.
