Relation between the expression of P-gp and GST-pi in oral and maxillofacial squamous carcinoma and chemoresistance.
- Author:
Qing XU
1
;
Guochu LIN
;
Wantao CHEN
;
Xiaojian ZHOU
;
Lisong LIN
Author Information
- Publication Type:Journal Article
- MeSH: ATP-Binding Cassette, Sub-Family B, Member 1; analysis; Carcinoma, Squamous Cell; chemistry; drug therapy; Drug Resistance, Neoplasm; Facial Neoplasms; chemistry; drug therapy; Formazans; Glutathione S-Transferase pi; Glutathione Transferase; analysis; Humans; Immunohistochemistry; Isoenzymes; analysis; Maxillary Neoplasms; chemistry; drug therapy; Mouth Neoplasms; chemistry; drug therapy; Tetrazolium Salts
- From: Chinese Journal of Stomatology 2002;37(2):90-93
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigating the relation between the expression of P-glycoprotein and Glutathione transferase-pi and the chemoresistance.
METHODSThe expressions of these two proteins in patients with oral and maxillofacial squamous carcinoma and normal oral tissues were detected by immunohistochemistry.
RESULTSThe positive expression rate of P-gp and GST-pi in oral and maxillofacial malignant tumor was 57.1% and 53.6% respectively, and no expression in normal oral tissues; the expression of GST-pi was relevant to the resistance to cisplatin, while the expression of P-gp was relevant to the resistance to chemotherapeutic drug in general.
CONCLUSIONSThe method of immunohistochemistry combining MTT assay in vitro may become an efficient way to predict the sensitivity to chemotherapeutic drug.
