The role of mitogen-activated protein kinase (MAPK) pathway in the action mechanism of PYM-induced KB cells apoptosis.
- Author:
Guowei DAI
1
;
Zhenkang ZHANG
;
Mingyong ZHOU
;
Shifeng YU
Author Information
- Publication Type:Journal Article
- MeSH: Antibiotics, Antineoplastic; pharmacology; Apoptosis; drug effects; Bleomycin; analogs & derivatives; pharmacology; Humans; KB Cells; Mitogen-Activated Protein Kinases; physiology; p38 Mitogen-Activated Protein Kinases
- From: Chinese Journal of Stomatology 2002;37(2):97-98
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the role of mitogen-activated protein kinase (MAPK) pathway in the action mechanism of PYM-induced KB cell apoptosis.
METHODSWestern blot analysis was used to investigate the expression of the mitogen-activated protein kinase.
RESULTSWhen treated with PYM in cultured KB cells, the extracellular signal-regulated kinase (ERKl/2) showed a dose-and time-dependent decreasing in phosphorylation status of these proteins through a western blot analysis, whereas protein levels of p38 MAPK remained unchanged.
CONCLUSIONSThe mitogen-activated protein kinase (MAPK) pathway may play an important ro1e in PYM-induced apoptosis of KB cells.
