Expression of VEGF, EGFR, p16 in lip cancers and oral squamous cell carcinomas and their clinic significance.
- Author:
Wenjun YANG
1
;
Zhaoquan LIN
;
Liangzhong LI
;
Guoshan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Squamous Cell; chemistry; pathology; Cyclin-Dependent Kinase Inhibitor p16; analysis; Endothelial Growth Factors; analysis; Female; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; analysis; Lip Neoplasms; chemistry; pathology; Lymphokines; analysis; Male; Middle Aged; Mouth Neoplasms; chemistry; pathology; Receptor, Epidermal Growth Factor; analysis; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors
- From: Chinese Journal of Stomatology 2002;37(2):99-101
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expression of vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), p16 protein in lip cancers and oral squamous cell carcinoma (OSCC) as well as their clinicopathological significance.
METHODSImmunohistochemisty for expression VEGF, EGFR, P16 were carried out in 69 cases of lip cancers and OSCC.
RESULTSExpression of VEGF, EGFR, p16 protein in OSCC and lip cancers was respectively 71.01%, 46.37%, 28.98% and there were no significance between their positive expressions (P > 0.05) as well as in different sites of them (P > 0.05). Expression of VEGF was respectively 71.01% in cancers and 10.00% in non-tumor tissues, there was statistic significance among those (P < 0.05).
CONCLUSIONSThe results show that there is no correlation to the expression of VEGF, EGFR and P16 protein in OSCC and lip cancers. It is suggests that the expression of VEGF might become one of the useful markers for OSCC.
