The relationship between tumor necrosis factor A-308 gene polymorphism and susceptibility of severe periodontitis in adults.
- Author:
Wei QIAN
1
;
Jincai ZHANG
;
Yunhui ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Genetic Predisposition to Disease; HLA-DR4 Antigen; genetics; Humans; Periodontitis; genetics; Polymerase Chain Reaction; Polymorphism, Genetic; Tumor Necrosis Factor-alpha; genetics
- From: Chinese Journal of Stomatology 2002;37(2):126-128
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between tumor necrosis factor A-308 gene polymorphism and susceptibility of severe periodontitis in adults.
METHODSBuccal swabs from 65 adult patients with severe periodontitis and 96 periodontal healthy adult controls were obtained. DNA was extracted from each sample using Chelex-100 method, then PCR-RFLP was performed to determine the TNFA-308 genotype. Data were analyzed by statistics software.
RESULTSA significant difference of genotype distribution was found between the patients and controls. The percentage of 1/1 type of the patients was much higher (P < 0.001). Risk Analysis showed odds ratio for allele 1 was 4.64.
CONCLUSIONThis study suggested that TNFA-308 allele 1 maybe a marker of susceptibility to severe periodontitis.
