Chromosome localization of the dentinogenesis imperfecta type II locus.
- Author:
Jun ZHAO
1
;
Xiaohai ZHANG
;
Ligeng WU
;
Zhi JIA
;
Qingsong ZHANG
;
Xiaoyan XING
Author Information
- Publication Type:Journal Article
- MeSH: Chromosome Mapping; Chromosomes, Human, Pair 4; genetics; DNA; genetics; Dentinogenesis Imperfecta; genetics; pathology; Family Health; Female; Genetic Linkage; Genetic Predisposition to Disease; genetics; Humans; Male; Microsatellite Repeats; Pedigree; Polymerase Chain Reaction
- From: Chinese Journal of Stomatology 2002;37(6):408-411
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the linkage between dentinogenesis imperfecta type II and chromosome 4q21 in a Tianjin-Tanggu family of the Hui nationality.
METHODSBlood samples were collected from 13 family members. DNAs were analyzed with 8 STRP markers (D4S2915, D4S2932, GATA62A11, D4S2409, DSP STRP, SPP1 STRP, D4S1563, D4S1544) using fluorescence-based PCR. The linkage between eight markers on chromosome 4q21 and dentinogenesis imperfecta type II locus was tested respectively by lod score analysis.
RESULTSGenotype and haplotype were acquired. Genetic linkage analysis demonstrated the maximum lod score of eight STRPs were all larger than zero, in which five of them were larger than 1.
CONCLUSIONThe locus of dentinogenesis imperfecta type II in Chinese family is located on human chromosome 4q21, which indicated that the locus of Chinese Hui nationality should be the same as that of other reported European or American family.
