Detection of hepatitis C virus antibody in saliva and its clinical significance.
- Author:
Dongping ZHOU
1
;
Zongping YANG
;
Lei WANG
;
Yili FU
Author Information
- Publication Type:Journal Article
- MeSH: Antibodies, Viral; blood; immunology; Clinical Laboratory Techniques; methods; Hepacivirus; immunology; Hepatitis C; diagnosis; virology; Humans; Immunoenzyme Techniques; Saliva; immunology; virology; Sensitivity and Specificity
- From: Chinese Journal of Stomatology 2002;37(6):449-451
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect hepatitis C virus (HCV) antibody in saliva and find its clinical significance.
METHODSSera and saliva samples from eighty-six patients were parallely detected HCV antibodies (anti-HCV) with EIA using a modified protocol.
RESULTSTwenty-nine of 86 patients were positive for anti-HCV in sera samples; and, 27/29 were also anti-HCV positive with saliva samples. For the 57 anti-HCV negative sera, the saliva samples were all negative. Comparing with the results of sera, the sensitivity (93.1%, 27/29) and specificity (100%, 57/57) of salivary detection for anti-HCV could be accepted.
CONCLUSIONIf the results of sera are considered as "golden standard", these results suggest that tests on saliva can be useful in HCV clinical diagnosis and epidemiological studies for estimating the prevalence of HCV in populations.
