Discriminating Ability of Scanning Laser Polarimetry with Variable Corneal Compensation in Normal and Glaucomatous Eyes.
- Author:
Jong Uk HWANG
1
;
Ji Yong JUNG
;
Hyun Soo CHO
;
Michael Scott KOOK
Author Information
1. Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. mskook@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Anterior segment birefringence;
Early detection of glaucoma;
Early glaucoma;
Scanning laser polarimetry;
Variable corneal compensation
- MeSH:
Compensation and Redress*;
Glaucoma;
Humans;
Nerve Fibers;
Retinaldehyde;
ROC Curve;
Scanning Laser Polarimetry*;
Sensitivity and Specificity;
Visual Fields
- From:Journal of the Korean Ophthalmological Society
2006;47(2):253-263
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We investigated the diagnostic ability of scanning laser polarimetry with variable corneal compensation (GDx VCC) parameters to distinguish glaucomatous eyes with different degrees of visual field abnormality from normal eyes. METHODS: Subjects were divided into a control group (n=47) and an early to moderate glaucoma group (n=100). The latter included 53 early glaucoma patients (mean deviation > -6dB with a Humphrey Field Analyzer). Using a receiver operating characteristic (ROC) curve, the diagnostic power of GDx VCC parameters was analyzed and the correlations between those parameters and Humphrey Field Analyzer (HFA) indices were statistically analyzed. RESULTS: Nerve fiber indicator (NFI) provided the best discriminating ability with the highest area under the ROC curve (AUROC) value for detecting eyes with early to moderate perimetric glaucoma. TSNIT average showed the highest AUROC value for detecting eyes with early perimetric glaucoma. The optimal NFI cut-off value to discriminate between the control group and early to moderate group was 22, offering the best combination of sensitivity (88.0%) and specificity (83.0%). The optimal TSNIT average cut-off value to discriminate between the control group and early glaucoma group was 53.49 micrometer, providing the best combination of sensitivity (84.9%) and specificity (85.1%). Most of the thickness parameters showed higher AUROC values than those of the ratio or modulation parameters. A statistically significant correlation was found between the GDx VCC parameters and HFA indices. CONCLUSIONS: Measurement of the retinal nerve fiber layer (RNFL) by scanning laser polarimetry with variable corneal compensation is useful in discriminating between normal and glaucomatous eyes.
