Preparation and in vitro release characteristics of curcumin loaded biodegradable microspheres.
- Author:
Haiou WANG
1
;
Pan LI
;
Liangke ZHANG
;
Jingqing ZHANG
;
Xu LING
;
Haitao RAN
Author Information
- Publication Type:Journal Article
- MeSH: Biocompatible Materials; chemistry; Curcumin; chemistry; Drug Carriers; chemistry; Microspheres; Particle Size; Polyglactin 910; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(23):3021-3024
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare curcumin-loaded poly-(D,L-lactide-co-glycolide) microspheres and study its release characteristics in vitro.
METHODCurcumin-loaded poly-(D,L-lactide-co-glycolide) microspheres were prepared by W/O/W emulsification solvent-evaporation process. The microspheres were characterized in terms of morphology, size, encapsulation efficiency, the rate of drug loading and in vitro drug release.
RESULTThe formed microspheres were spherical with smooth surfaces. The distribution of particle size was uniform and average size was 1 151 nm. The rate of drug loading was (1.98 +/- 0.14)% and the encapsulation efficiency was (59.44 +/- 4.05)%. In vitro release study revealed that the 71-hour accumulative release percentage reached 77%.
CONCLUSIONCurcumin loaded poly-(D,L-lactide-co-glycolide) microspheres are prepared successfully and show good sustained-release characteristics.
