Steroidal alkaloids of from Veratrum dahuricum.

Author: Lang ZHAO ¹ ; Zhiqiang OU ; Kan WANG ; Hongzheng FU
Author Information

1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Publication Type:Journal Article
MeSH: Alkaloids; chemistry; Drugs, Chinese Herbal; chemistry; Isomerism; Steroids; chemistry; Veratrum; chemistry
From: China Journal of Chinese Materia Medica 2009;34(23):3039-3042
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the steroidal alkaloids in Veratrum dahuricum.
METHODThe compounds were isolated and purified by various column chromatographic methods. Their structures were identified by spectroscopic analysis.
RESULTFive compounds were isolated and identified as (20R, 22S, 25S)-veratra-5,13-dien-3beta-ol (1), angeloylzygadenine (2), 15-O-(2-methylbutanoyl)-3-O-veatroylprotoverine (3), 20-isoveratramine (4), veratramine (5).
CONCLUSIONCompound 1 was a new compound, compounds 24 were obtained from the plant for the first time.