Pharmacokinetics of fangchinoline and tetrandrine in rats.
- Author:
Zhonghong LI
1
;
Xialei FAN
;
Meiming CAI
;
Zhihong YANG
;
Jian YING
;
Guifen QIANG
;
Guanhua DU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Benzylisoquinolines; administration & dosage; pharmacokinetics; Drugs, Chinese Herbal; administration & dosage; pharmacokinetics; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2009;34(23):3110-3113
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the pharmacokinetics profile of fangchinoline and tetrandrine in rats after administration of single compound and mixture with other intergradient in traditional prescription.
METHODA method for determination of fangchinoline and tetrandrine in rat plasma by using HPLC-MS has been developed and validated. The pharmacokinetics of two compounds and two compounds in the effective component group (ECG) of Xiaoxuming decoction were compared.
RESULTCompared with the single dose of compound experiment results, the t(max) of fangchinoline and tetrandrine were longer than those in the single dose of ECG experiment. At the meanwhile the rest parameter showed no significant difference.
CONCLUSIONOther components in the ECG of Xiaoxuming decoction delayed the absorption rate of fangchinoline and tetrandrine, the bioavailability of two compounds were the same as that of the single dose of compound experiment.
