Corneal penetration of PAMAM dendrimers-coated puerarin liposomes.
- Author:
Yi LIU
1
;
Kaoxiang SUN
;
Wenjun YAO
;
Na LIANG
;
Hongjie MU
;
Rongcai LIANG
;
Chen YAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cornea; metabolism; Dendrimers; chemistry; metabolism; In Vitro Techniques; Isoflavones; chemistry; Liposomes; chemistry; metabolism; Rabbits
- From: China Journal of Chinese Materia Medica 2010;35(1):30-34
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the corneal penetration of PAMAM dendrimers-coated puerarin liposomes in rabbits.
METHODEvaluated PAMAM (G2, G3) dendrimers-coated puerarin liposomes were prepared and the in vitro transcorneal penetration were compared to puerarin drop solution and uncoated liposomes. The effect of different proportion of PAMAM to phospholipids in formulation on corneal penetration and the penetration parameters were investigated.
RESULTThe steady state fluxes and permeability coefficients of puerarin by PAMAM G2 (1.0%) and PAMAM G3 (0.5%) coated puerarin liposomes were greater than that by puerarin drop solution and uncoated liposomess (P < 0.01), meanwhile the PAMAM G2 (1.0%) and PAMAM G3 (0.5%) coated liposomes were better than other ratios of coated liposomes for improvement of corneal penetration (P < 0.01).
CONCLUSIONThe PAMAM coated liposomes is able to enhance the corneal penetration of puerarin and promising as an ocular drug carriers.
